CSN8 抗体-CSN8 Antibody

CSN8 抗体，CSN8 Antibody，CSN8 抗体,CSN8 Antibody

产品名称：CSN8 抗体-CSN8 Antibody

产品货号：PSI-4601-0.02mg

产品规格：0.02mg

背景资料：CSN8 Antibody: The COP9 signalosome (CSN) is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-comlpexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.

保存建议：CSN8 抗体-CSN8 Antibody stored at 4℃ for three months and -20℃, stable for up to one year

应用类型：E, WB

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