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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 免疫原:
ZBP1 antibody was raised against an 18 amino acid synthetic peptide from near the carboxy terminus of human ZBP1.<br>The immunogen is located within the last 50 amino acids of ZBP1.
- 保存条件:
stored at 4℃ for three months and -20℃, stable for up to one year
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
E, WB, IHC-P, IF
- 抗体英文名:
ZBP1 Antibody
- 抗体名:
ZBP1 Antibody
- 规格:
0.02mg
ZBP1 抗体,ZBP1 Antibody,ZBP1 抗体,ZBP1 Antibody
产品名称:ZBP1 抗体-ZBP1 Antibody
产品货号:PSI-4401-0.02mg
产品规格:0.02mg
背景资料:ZBP1 Antibody: Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK).
保存建议:ZBP1 抗体-ZBP1 Antibody stored at 4℃ for three months and -20℃, stable for up to one year
应用类型:E, WB, IHC-P, IF
点击:ZBP1 抗体-ZBP1 Antibody查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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- 作者
- 内容
- 询问日期
文献和实验Section.01 炎症开关:ZBP1 ZBP1 是一种重要的病原体感知蛋白,能够识别病毒诱导形成的 Z-DNA 或 Z-RNA 构象,并进一步激活 RIPK3-MLKL 信号轴,引发坏死性凋亡和强烈的炎症因子释放。与传统靶向 RIPK3、MLKL 等下游分子的策略相比,直接干预 ZBP1 这一“上游开关”,有望更彻底地抑制炎症级联反应,同时降低对正常生理过程的干扰。 近年来,Z-DNA
在免疫反应方面,基于抗原的刺激在体内形成、并与抗原作特异性结合的蛋白质之总称。其化学实质是免疫球蛋白。抗体,按照抗原抗体反应的类型可分别称为沉淀素、凝集素、溶血素、溶菌素、抗毒素、中和抗体等,但这些并不等于有相应的不同抗体存在,一般多只表明抗体反应的多样性而已。抗体在血清中含量最多(体液抗体=humoral antibody);含有某特定抗体的血清称为抗血或免疫血清。
机体在抗原物质刺激下,由B细胞分化成的浆细胞所产生的、可与相应抗原发生特异性结合反应的免疫球蛋白。因为最初有人用电泳证明血清中抗体活性在γ球蛋白部分,故曾把抗体统称为两种(γ)球蛋白。后来证明,抗体并不都在γ区;而且位于γ区的球蛋白,也不一定都具有抗体活性。1964年,世界卫生组织举行专门会议,将具有抗体活性以及与抗体相关的球蛋白统称为免疫球蛋白(Ig)。如骨髓瘤蛋白,巨球蛋白血症、冷球蛋白血症等患者血清中存在的异常免疫球蛋白以及“正常人”天然存在的免疫
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