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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Integrin alpha 4 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human Integrin alpha 4.<br>The immunogen is located within the last 50 amino acids of Integrin alpha 4.
- 保存条件:
stored at 4℃ for three months and -20℃, stable for up to one year
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
E, WB
- 抗体英文名:
Integrin alpha 4 Antibody
- 抗体名:
Integrin alpha 4 Antibody
- 规格:
0.02mg
Integrin alpha 4 抗体,Integrin alpha 4 Antibody,Integrin alpha 4 抗体,Integrin alpha 4 Antibody
产品名称:Integrin alpha 4 抗体-Integrin alpha 4 Antibody
产品货号:PSI-4783-0.02mg
产品规格:0.02mg
背景资料:Integrin alpha 4 Antibody: The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
保存建议:Integrin alpha 4 抗体-Integrin alpha 4 Antibody stored at 4℃ for three months and -20℃, stable for up to one year
应用类型:E, WB
点击:Integrin alpha 4 抗体-Integrin alpha 4 Antibody查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验marrow. The prime suspect: an adhesion molecule called alpha2 integrin. The molecule showed increased expression on memory cells, and its ligand is predominantly expressed in bone marrow tissue. Also, when the researchers blocked alpha2 integrin
;2与配体的作用可以协同TCR/CD3介导的淋巴细胞增殖和细胞因子产生,提示淋巴细胞与胞外基质的作用可能影响其活化状态。此外单核细胞及中性粒细胞表面integrin分子与配体的作用也参与诱导细胞产生炎症因子的过程。 (一)粘附分子与细胞内酪氨酸磷酸化 酪氨酸磷酸化是细胞内信号传导的一个重要途径,而integrin分子与某些细胞内的酪氨酸磷酸化发生有关。血小板活化过程伴随着广泛的细胞内蛋白酪氨酸磷酸化,integrin分子&alpha
2-1 integrin分子的结构(示意图) 注:a .integrin分子电镜下所见(模式图),黑区部分显示integrin分子α、β亚单位所 组成的球部,为配体结合域; b.integrin分子的结构模式图,显示出α亚单位的二价阳离子(Mg2+ )结合区和α、 β亚单位的重复序列。 (一)粘合素分子的基本结构
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