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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Anti-PD-1 antibody (<strong>4065</strong>) was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human PD-1. <br> The immunogen is located within amino acids 210-260 of PD-1.
- 保存条件:
stored at 4℃ for three months and -20℃, stable for up to one year
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
E, WB, IHC-P, IF
- 抗体英文名:
PD-1 Antibody
- 抗体名:
PD-1 Antibody
- 规格:
0.02mg
PD-1 抗体,PD-1 Antibody,PD-1 抗体,PD-1 Antibody
产品名称:PD-1 抗体-PD-1 Antibody
产品货号:PSI-4065-0.02mg
产品规格:0.02mg
背景资料:PD-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases.
保存建议:PD-1 抗体-PD-1 Antibody stored at 4℃ for three months and -20℃, stable for up to one year
应用类型:E, WB, IHC-P, IF
点击:PD-1 抗体-PD-1 Antibody查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验这种水果将助力癌症治疗?增强免疫治疗效果,有望克服 PD-1 耐药难题!
素 C、花青素类物质,已被证明可以通过增加肠道中嗜粘液杆菌(A.muciniphila)和双歧杆菌(Bifidobacterium)的丰度,对小鼠的肥胖和相关代谢紊乱发挥保护性作用。 2022 年 1 月 14 日,来自加拿大蒙特利尔大学研究中心的 Bertrand Routy 团队在 Cancer Discovery 上发表了题为 A natural polyphenol exerts antitumor activity and circumvents anti-PD-1 resistance
。类风湿关节炎患者抗PD-L1自身抗体的阳性率高于正常人,活化的CD4+、CD8+、CD45RO+T细胞表面PD-L1呈高水平表达,抗PD-L1自身抗体在体外能够协同刺激CD4+T细胞增殖,该自身抗体可能是通过诱导异常的T细胞应答而促进类风湿关节炎进展[21]。在系统性红斑狼疮的1个易感位点(SLEB2)的凋亡基因(PDCD1,也称PD-1)中发现,单链核苷酸的多态性与欧洲人和墨西哥人系统性红斑狼疮的发病有关[22]。PD-1—PD-L也参与了抑制移植排斥反应。多数正常组织和移植心脏中,PD-1
在免疫反应方面,基于抗原的刺激在体内形成、并与抗原作特异性结合的蛋白质之总称。其化学实质是免疫球蛋白。抗体,按照抗原抗体反应的类型可分别称为沉淀素、凝集素、溶血素、溶菌素、抗毒素、中和抗体等,但这些并不等于有相应的不同抗体存在,一般多只表明抗体反应的多样性而已。抗体在血清中含量最多(体液抗体=humoral antibody);含有某特定抗体的血清称为抗血或免疫血清。
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