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- ProSci
- 美国
- PSI-3515-0.02mg
- 2025年07月07日
- E, WB, IP
- 兔
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
PTEN antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human PTEN.<br>The immunogen is located within the last 50 amino acids of PTEN.
- 保存条件：
stored at 4℃ for three months and -20℃, stable for up to one year
- 保质期：
1年
- 级别：
科研级别
- 库存：
100
- 供应商：
艾美捷科技
- 宿主：
兔
- 应用范围：
E, WB, IP
- 抗体英文名：
PTEN Antibody
- 抗体名：
PTEN Antibody
- 规格：
0.02mg
PTEN 抗体，PTEN Antibody，PTEN 抗体,PTEN Antibody
产品名称：PTEN 抗体-PTEN Antibody
产品货号：PSI-3515-0.02mg
产品规格：0.02mg
背景资料：PTEN Antibody: PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a dual-specificity phosphatase (with both protein and lipid phosphatase activity) first identified as a tumor suppressor gene. PTEN indirectly activates the AKT/PI3K pathway, an important signaling pathway for cell growth and proliferation by keeping levels of the second messenger PIP3 low, thereby preventing phosphoinositide-dependent kinase-1 (PDK-1) from phosphorylating and activating AKT. Expression of wild-type PTEN causes growth arrest in many cancer cell lines, but expression of a PTEN protein containing a mutation that blocks its lipid phosphatase activity failed to suppress growth of glioma cell lines suggesting that the tumor suppressive effect of PTEN is mediated solely by its lipid phosphatase activity. Other activities include the inhibition of insulin stimulated MAPK activation by blocking the insulin-receptor substrate (IRS)-1 phosphorylation and assembly of the IRS-1/Grb2/Sos complex.
保存建议：PTEN 抗体-PTEN Antibody stored at 4℃ for three months and -20℃, stable for up to one year
应用类型：E, WB, IP
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文献和实验Genetic evidence strongly suggested that a tumor suppressor was located on chromosome 10. During the development of glioblastoma, one copy of chromosome 10 was typically lost (1 ). Cytogenetic and molecular analysis revealed partial
Measurement of PTEN Activity in vivo by Imaging Phosphorylated Akt
-dependent activation and phosphorylation of the survival kinase Akt can be used as readout for cellular PTEN activity. Here we have outlined a detailed procedure employing a phosphoserine-specific anti-Akt antibody to examine the content of phosphorylated
18 Direct Sequencing for Cowden Syndrome Gene PTEN (MMAC1) Mutations
Cowden syndrome is a rare dominantly inherited condition with predisposition to benign hamartomatous polyposis of the intestine, as well as malignant tumors of the breast and thyroid, and possibly some other cancer types. Other features include
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