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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Anti-Bcl-2 antibody (<strong>3335</strong>) was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Bcl-2. <br> The immunogen is located within the first 50 amino acids of Bcl-2.
- 保存条件:
stored at 4℃ for three months and -20℃, stable for up to one year
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
E, WB, IHC-P, IF
- 抗体英文名:
Bcl-2 Antibody
- 抗体名:
Bcl-2 Antibody
- 规格:
0.02mg
Bcl-2 抗体,Bcl-2 Antibody,Bcl-2 抗体,Bcl-2 Antibody
产品名称:Bcl-2 抗体-Bcl-2 Antibody
产品货号:PSI-3335-0.02mg
产品规格:0.02mg
背景资料:Bcl-2 Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-2 is the founding member of a family of over 20 proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-2 is an inner mitochondrial membrane protein that inhibits apoptosis. It is thought to act by interacting with pro-apoptotic Bcl-2 family members such as Bak and Bad. Overexpression of Bcl-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
保存建议:Bcl-2 抗体-Bcl-2 Antibody stored at 4℃ for three months and -20℃, stable for up to one year
应用类型:E, WB, IHC-P, IF
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文献和实验【求助】如果要证明Bcl-2和RARP活性,应该做什么实验?
eeflying 目前有两种化合物,分别为Bcl-2和PARP的抑制剂, 虽然这两个指标通常作为细胞凋亡的指标常用于分子生物实验, 但是,如何证明这两个分子被抑制的实验却第一次碰到, 请各位战友支招,我要直接检测哪个蛋白的WB 或者做什么实验合适? magichunter 用western检测bcl-2的含量变化,检测PARP活性裂解片段的含量变化以及原型态PARP的含量
Bcl-2蛋白是bcl-2 原癌基因的编码产物,是细胞存活促进因子,属膜整合蛋白,分子量为26kDa, 定位于线粒体、内质网和连续的核周膜。Bcl-2蛋白家族是一个特别的家族,成员中有些促进凋亡,如Bad、Bid 、Bax,有些成员阻止细胞凋亡,如Bcl-2、 Bcl-x、Bcl-w。Bcl-2能够阻止细胞色素c从线粒体释放到细胞质,从而抑制了细胞凋亡。
bcl-2 原癌基因(bcl-2 protooncogene)
人的B-淋巴细胞(B-cell lymphomas)中染色体易位激活的原癌基因。bcl即是B-淋巴细胞的英文缩写。该基因编码一种细胞质膜蛋白,能够抑制细胞的程序性死亡。bcl-2原癌基因与秀丽隐杆线虫的ced-9基因同源。
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