DcR2/TRAIL R4 Protein, Rhesus,

蛋白长度：A DNA sequence encoding the rhesus TNFRSF10D (XP_001107922.1) (Met1-Leu206) was expressed with the Fc region of human IgG1 at the C-terminus.

性质：

表达系统：HEK293 Cells

种属：Rhesus

氨基酸序：Met1-Leu206

标签类型：C-hFc

分子量：The recombinant rhesus TNFRSF10D comprises 392 amino acids and has a calculated molecular mass of 42.9 KDa.

活性：Measured by its binding ability in a functional ELISA.Immobilized Rhesus TNFSF10 (Cat:PK54065E0) at 10 μg/ml (100 μl/well) can bind Rhesus TNFRSF10D-Fc, The ECof Rhesus TNFRSF10D-Fc is 7.8-18.1 ng/ml.

内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.

基因名称：tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain

通用名：TNFRSF10D

蛋白序参考：XP_001107922.1

总结：Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), also known as TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4), CD264, and Decoy receptor 2, is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. TRAIL R4/CD264/TNFRSF10D is widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. TRAIL R4/CD264/TNFRSF10D is also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. The signaling capacity of TRAIL R4 is similar to that of TRAIL R1 and TRAIL R2 with respect to NF-κB activation, but differs in its inability to induce apoptosis. TRAIL R4 retains a C-terminal element containing one third of a consensus death domain motif. Transient overexpression of TRAIL R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAIL R4 may be inhibition of TRAIL cytotoxicity.

形式：Lyophilized

纯度：> 90 % as determined by SDS-PAGE.

储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

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