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- 详细信息
- 技术资料
- 保存条件：
Stable for 1 year at -4165°C or below from date of shipment.
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 规格：
50 ug
蛋白长度：A DNA sequence encoding the Rhesus PCSK9 (NP_001106130.1) (Met 1-Gln 692) precursor was expressed, fused with a polyhistidine tag at the C-terminus.
性质：
表达系统：HEK293 Cells
种属：Rhesus
氨基酸序：Met1-Gln692
标签类型：C-His
分子量：The recombinant Rhesus PCSK9 consists of 673 amino acids and predicts a molecular mass of 72.7 kDa. As a result of glycosylation and proteolytic digestion, it migrates as doublet with apparent molecular mass of 20 kDa and 62 kDa corresponding to the pro domain and mature form respectively in SDS-PAGE under reducing conditions.
活性：1. Measured by its ability to bind biotinylated human LDLR in a functional ELISA. 2. Measured by its ability to bind biotinylated mouse LDLR in a functional ELISA.
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.
基因名称：proprotein convertase subtilisin/kexin type 9
通用名：PCSK9
蛋白序参考：NP_001106130.1
总结：Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
形式：Lyophilized
纯度：> 95 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：
性质：
表达系统：HEK293 Cells
种属：Rhesus
氨基酸序：Met1-Gln692
标签类型：C-His
分子量：The recombinant Rhesus PCSK9 consists of 673 amino acids and predicts a molecular mass of 72.7 kDa. As a result of glycosylation and proteolytic digestion, it migrates as doublet with apparent molecular mass of 20 kDa and 62 kDa corresponding to the pro domain and mature form respectively in SDS-PAGE under reducing conditions.
活性：1. Measured by its ability to bind biotinylated human LDLR in a functional ELISA. 2. Measured by its ability to bind biotinylated mouse LDLR in a functional ELISA.
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.
基因名称：proprotein convertase subtilisin/kexin type 9
通用名：PCSK9
蛋白序参考：NP_001106130.1
总结：Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
形式：Lyophilized
纯度：> 95 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：
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PCSK9 Protein, Rhesus, Recombinant (His Tag)
$3215
