IL1R1 Protein, Cynomolgus, Rec

蛋白长度：A DNA sequence encoding the cynomolgus IL1R1 (G7NAT4) (Met1-Thr332) was expressed with the Fc region of human IgG1 at the C-terminus.

性质：

表达系统：HEK293 Cells

种属：Cynomolgus

氨基酸序：Met1-Thr332

标签类型：C-hFc

分子量：The recombinant cynomolgus IL1R1 is a disulfide-linked homodimer. The reduced monomer comprises 553 amino acids and has a calculated molecular mass of 62.9 KDa.The apparent molecular mass of the protein is approximately 73-93 KDa respectively in SDS-PAGE.

活性：Measured by its binding ability in a functional ELISA. Immobilized human IL1RA (Cat:10123-HNAE) at 10 μg/ml (100 μl/well) can bind Cynomolgus IL1R1-Fc, The ECof Cynomolgus IL1R1-Fc is 0.04-0.08 μg/mL.

内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.

基因名称：interleukin 1 receptor, type I

通用名：IL1R1

蛋白序参考：

总结：Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.

形式：Lyophilized

纯度：> 95 % as determined by SDS-PAGE.

储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

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