- $3865
- Leading Biology
- 美国
- PK54063M4
- 2025年07月10日
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- 详细信息
- 技术资料
- 保存条件：
Stable for 1 year at -4083°C or below from date of shipment.
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 规格：
100 ug
蛋白长度：A DNA sequence encoding the Rhesus ErbB2 (XP_001090430.1) extracellular domain (Met 1-Thr 652) was fused with the Fc region of human IgG1 at the C-terminus.
性质：
表达系统：HEK293 Cells
种属：Rhesus
氨基酸序：Met1-Thr652
标签类型：C-hFc
分子量：The recombinant Rhesus ErbB2/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 870 amino acids and predicts a molecular mass of 96.3 kDa. As a result of glycosylation, rhesus ErbB2/Fc monomer migrates as an approximately 130 kDa band in SDS-PAGE under reducing conditions.
活性：Immobilized Her2/ERBB2 Protein, Rhesus, Recombinant (hFc Tag)(Cat:PK54063M4) at 2 μg/ml (100 μl/well) can bind Anti-Erbb2 Antibody (Trastuzumab)(Cat:68046-H002), the ECis 15-70 ng/mL.
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.
基因名称：erb-b2 receptor tyrosine kinase 2
通用名：ERBB2
蛋白序参考：XP_001090430.1
总结：Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
形式：Lyophilized
纯度：> 90 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：
性质：
表达系统：HEK293 Cells
种属：Rhesus
氨基酸序：Met1-Thr652
标签类型：C-hFc
分子量：The recombinant Rhesus ErbB2/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 870 amino acids and predicts a molecular mass of 96.3 kDa. As a result of glycosylation, rhesus ErbB2/Fc monomer migrates as an approximately 130 kDa band in SDS-PAGE under reducing conditions.
活性：Immobilized Her2/ERBB2 Protein, Rhesus, Recombinant (hFc Tag)(Cat:PK54063M4) at 2 μg/ml (100 μl/well) can bind Anti-Erbb2 Antibody (Trastuzumab)(Cat:68046-H002), the ECis 15-70 ng/mL.
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.
基因名称：erb-b2 receptor tyrosine kinase 2
通用名：ERBB2
蛋白序参考：XP_001090430.1
总结：Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
形式：Lyophilized
纯度：> 90 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：
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Her2/ERBB2 Protein, Rhesus, Recombinant (hFc Tag)
$3865
