SLAMF6 Protein, Mouse, Recombi

蛋白长度：A DNA sequence encoding the mouse SLAMF6 (NP_109635.1) extracellular domain (Met 1-Asn 239) was fused with a polyhistidine tag at the C-terminus.

性质：

表达系统：HEK293 Cells

种属：Mouse

氨基酸序：Met1-Asn239

标签类型：C-His

分子量：The recombinant mouse SLAMF6 consists of 220 amino acids and has a predicted molecular mass of 24.4 kD. The apparent molecular mass of the rmSLAMF6 protein is approximately 40-45 kDa in SDS-PAGE under reducing conditions.

活性：Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA.

内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.

基因名称：SLAM family member 6

通用名：SLAMF6

蛋白序参考：NP_109635.1

总结：SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly18, is a single-pass type I membrane protein that belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly18 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly18 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly18 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly18 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly18 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

形式：Lyophilized

纯度：> 95 % as determined by SDS-PAGE.

储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

别名：KAL1 Protein, Mouse; KAL1b Protein, Mouse; Ly108 Protein, Mouse; NTB-A Protein, Mouse; NTBA Protein, Mouse; SF2000 Protein, Mouse