CD155/PVR Protein, Mouse, Reco

蛋白长度：A DNA sequence encoding the mouse PVR (NP_081790.1) (Met1-Arg345) was expressed with the Fc region of mouse IgG2a at the C-terminus.

性质：

表达系统：HEK293 Cells

种属：Mouse

氨基酸序：Met1-Arg345

标签类型：C-mFc

分子量：The recombinant mouse PVR consists of 550 amino acids and predicts a molecular mass of 60.78 kDa.

活性：1. Measured by its binding ability in a functional ELISA. Immobilized TIGIT Protein, Human, Recombinant (ECD, His Tag)(Cat:PH52206M2) at 2 μg/ml (100 μl/well) can bind CD155/PVR Protein, Mouse, Recombinant (mFc Tag)(Cat:PM53013M4), the ECof CD155/PVR Protein, Mouse, Recombinant (mFc Tag) is 25-140 ng/mL. 2. Immobilized mouse CD155 (mFc Tag)（PM53013M4） at 2 μg/mL (100μL/well) can bind Mouse TIGIT-His, HPLC-verified (HPLC-PM53006M2), the ECof Mouse TIGIT-His, HPLC-verified (HPLC-PM53006M2) is 300-900 ng/mL.

内毒素：< 1.0 EU per μg protein as determined by the LAL method.

基因名称：poliovirus receptor

通用名：PVR

蛋白序参考：NP_081790.1

总结：CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

形式：Lyophilized

纯度：> 95 % as determined by SDS-PAGE.

储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

别名：3830421F03Rik Protein, Mouse; CD155 Protein, Mouse; D7Ertd458e Protein, Mouse; HVED Protein, Mouse; mE4 Protein, Mouse; necl-5 Protein, Mouse; PVS Protein, Mouse; Taa1 Protein, Mouse; Tage4 Protein, Mouse