PDGFRB Protein, Human, Recombi

蛋白长度：A DNA sequence encoding the human PDGFRβ (NP_002600.1) extracellular domain (Met 1-Lys 531) was expressed, with a C-terminal polyhistidine tag.

性质：

表达系统：HEK293 Cells

种属：Human

氨基酸序：Met1-Lys531

标签类型：C-His

分子量：The secreted recombinant human PDGFRβ comprises 510 amino acids and predicts a molecular mass of 57.6 kDa. It migrates as an approximately 95-100 kDa band in SDS-PAGE under reducing conditions.

活性：Measured by its binding ability in a functional ELISA. Immobilized PDGFRβ-His at 10 μg/ml (100 μl/well) can bind Cynomolgus PDGFB (Cat:90030-C04H), The ECof Cynomolgus PDGFB (Cat:90030-C04H) is 3-8 ng/ml.

内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.

基因名称：platelet-derived growth factor receptor, beta polypeptide

通用名：PDGFRB

蛋白序参考：NP_002600.1

总结：The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.

形式：Lyophilized

纯度：> 90 % as determined by SDS-PAGE.

储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

别名：CD140B Protein, Human; IBGC4 Protein, Human; IMF1 Protein, Human; JTK12 Protein, Human; KOGS Protein, Human; PDGFR Protein, Human; PDGFR-1 Protein, Human; PDGFR1 Protein, Human; PENTT Protein, Human