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- Leading Biology
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- PH52465M2
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- 详细信息
- 技术资料
- 保存条件：
Stable for 1 year at -2485°C or below from date of shipment.
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 规格：
100 ug
蛋白长度：A DNA sequence encoding the extracellular domain of human CD8A (NP_001759.3) (Met1-Asp182) was expressed with a C-terminal polyhistidine tag.
性质：
表达系统：CHO Stable Cells
种属：Human
氨基酸序：Met1-Asp182
标签类型：C-His
分子量：The recombinant human CD8A consists of 172 amino acids and predicts a molecular mass of 19 kDa. As a result of glycosylation, rh CD8A migrates as an approximately 28 kDa band in SDS-PAGE under reducing conditions.
活性：Measured by its ability to bind biotinylated Beta-2 microglobulin Protein, Human, Recombinant (His Tag)(Cat:PH52464M2) in a functional ELISA.
内毒素：< 1.0 EU per μg protein as determined by the LAL method.
基因名称：CD8a molecule
通用名：CD8A
蛋白序参考：NP_001759.3
总结：T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
形式：Lyophilized
纯度：> 90 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：CD8 Protein, Human; CD8 alpha Protein, Human; Leu-2 Protein, Human; Leu2 Protein, Human; MAL Protein, Human; p32 Protein, Human; p32 186910 Protein, Human
性质：
表达系统：CHO Stable Cells
种属：Human
氨基酸序：Met1-Asp182
标签类型：C-His
分子量：The recombinant human CD8A consists of 172 amino acids and predicts a molecular mass of 19 kDa. As a result of glycosylation, rh CD8A migrates as an approximately 28 kDa band in SDS-PAGE under reducing conditions.
活性：Measured by its ability to bind biotinylated Beta-2 microglobulin Protein, Human, Recombinant (His Tag)(Cat:PH52464M2) in a functional ELISA.
内毒素：< 1.0 EU per μg protein as determined by the LAL method.
基因名称：CD8a molecule
通用名：CD8A
蛋白序参考：NP_001759.3
总结：T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
形式：Lyophilized
纯度：> 90 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：CD8 Protein, Human; CD8 alpha Protein, Human; Leu-2 Protein, Human; Leu2 Protein, Human; MAL Protein, Human; p32 Protein, Human; p32 186910 Protein, Human
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CD8 alpha Protein, Human, Recombinant (ECD, His Tag)
$5810
