LAG3 Protein, Human, Recombina

蛋白长度：A DNA sequence encoding the human LAG3 (NP_002277.4) (Met1-Leu450) was expressed with the Fc region of human IgG1 at the C-terminus.

性质：

表达系统：HEK293 Cells

种属：Human

氨基酸序：Met1-Leu450

标签类型：C-hFc

分子量：The recombinant human LAG3 consists of 666 amino acids and predicts a molecular mass of 72.9 kDa. As a result of glycosylation, it migrates as an approximately 84.19 KDa band in SDS-PAGE under reducing conditions.

活性：Immobilized LAG3 Protein, Human, Recombinant (ECD, hFc Tag)(Cat:PH51594M4) at 2 μg/mL (100 μL/well) can bind Anti-LAG3(BMS)-IgG4 Antibody (Relatlimab)(Cat:68075-H001), the ECis 8-40 ng/mL.

内毒素：< 1.0 EU per μg protein as determined by the LAL method.

基因名称：lymphocyte-activation gene 3

通用名：LAG3

蛋白序参考：NP_002277.4

总结：LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.

形式：Lyophilized

纯度：> 95 % as determined by SDS-PAGE.

储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

储存溶液：Lyophilized from sterile 20mM NaH2PO4, 150mM NaCl, 0.1M Arg, 0.1M Glu, 10% glycerol, 0.01% tween20, pH 7.4 Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

别名：CD223 Protein, Human; LAG-3 Protein, Human