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- 详细信息
- 技术资料
- 保存条件：
Stable for 1 year at -1305°C or below from date of shipment.
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 规格：
1 mg
蛋白长度：A DNA sequence encoding the extracellular domain (Met 1-Pro 621) of human G-CSF receptor (NP_000751.1) precursor was fused with a polyhistidine tag at the C-terminus.
性质：
表达系统：HEK293 Cells
种属：Human
氨基酸序：Met1-Pro621
标签类型：C-His
分子量：The mature recombinant human GCSFR consists of 608 amino acids and predicts a molecular mass of 68 kDa by SDS-PAGE under reducing conditions, the apparent molecular mass of rhGCSFR is approximately 92 kDa due to glycosylation.
活性：Measured by its ability to inhibit the GCSF-induced proliferation of NFS60 mouse myeloid cells.The EDfor this ettect is typically 50-250 ng/mL in the presence of 0.125ng/mL of recombinant human GCSF.
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.
基因名称：colony stimulating factor 3 receptor (granulocyte)
通用名：CSF3R
蛋白序参考：NP_000751.1
总结：Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.
形式：Lyophilized
纯度：> 85 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：CD114 Protein, Human; CSF3R Protein, Human; G-CSF R Protein, Human; GCSFR Protein, Human
性质：
表达系统：HEK293 Cells
种属：Human
氨基酸序：Met1-Pro621
标签类型：C-His
分子量：The mature recombinant human GCSFR consists of 608 amino acids and predicts a molecular mass of 68 kDa by SDS-PAGE under reducing conditions, the apparent molecular mass of rhGCSFR is approximately 92 kDa due to glycosylation.
活性：Measured by its ability to inhibit the GCSF-induced proliferation of NFS60 mouse myeloid cells.The EDfor this ettect is typically 50-250 ng/mL in the presence of 0.125ng/mL of recombinant human GCSF.
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.
基因名称：colony stimulating factor 3 receptor (granulocyte)
通用名：CSF3R
蛋白序参考：NP_000751.1
总结：Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.
形式：Lyophilized
纯度：> 85 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：CD114 Protein, Human; CSF3R Protein, Human; G-CSF R Protein, Human; GCSFR Protein, Human
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CSF3R/G-CSFR Protein, Human, Recombinant (His Tag)
$15000
