SUMO1 Protein, Human, Recombin

蛋白长度：A DNA sequence encoding the human SUMO1 (AAH66306.1) (Ser 2-Val 101) was expressed, with a polyhistide tag at the N-terminus.

性质：

表达系统：E. coli

种属：Human

氨基酸序：Ser2-Val101

标签类型：N-His

分子量：The recombinant human SUMO1 consisting of 107 amino acids and has a calculated molecular mass of 12.4 kDa. It migrates as an 22 kDa band in SDS-PAGE under reducing conditions as predicted.

活性：Measured by its ability to be proteolytically processed by SENP1.>50% of 1 μg Recombinant Human (rh) SUMO1 is cleaved by < 10 ng of recombinant human SENP.

内毒素：Please contact us for more information.

基因名称：small ubiquitin-like modifier 1

通用名：SUMO1

蛋白序参考：AAH66306.1

总结：Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX activity required for ROS generation. SUMO1 haploinsufficiency results in cleft lip and palate in animal models. SUMO1 gene variation in human non-syndromic cleft lip with or without cleft palate (NSCLP) development. SUMO-1 may be useful as a novel target for therapy in oral squamous cell carcinoma (SCC) as well as a clinical indicator for tumor recurrence together with Mdm2.

形式：Lyophilized

纯度：> 90 % as determined by SDS-PAGE.

储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

储存溶液：Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.5 Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

别名：DAP1 Protein, Human; GMP1 Protein, Human; OFC10 Protein, Human; PIC1 Protein, Human; SENP2 Protein, Human; SMT3 Protein, Human; SMT3C Protein, Human; SMT3H3 Protein, Human; UBL1 Protein, Human