- $3475
- Leading Biology
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- PH51032M3
- 2025年07月10日
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- 详细信息
- 技术资料
- 保存条件：
Stable for 1 year at -1052°C or below from date of shipment.
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 规格：
100 ug
蛋白长度：A DNA sequence encoding the human TNFSF14 (AAK26160.1) (Asp74-Val240) was expressed with the Fc region of rabbit IgG at the N-terminus..
性质：
表达系统：HEK293 Cells
种属：Human
氨基酸序：Asp74-Val240
标签类型：N-rFc
分子量：The recombinant human TNFSF14 consists of 418 amino acids and predicts a molecular mass of 45.7 kDa.
活性：Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC). The EDfor this effect is typically 5-25 ng/mL.
内毒素：< 1.0 EU per μg protein as determined by the LAL method.
基因名称：tumor necrosis factor (ligand) superfamily, member 14
通用名：TNFSF14
蛋白序参考：AAK26160.1
总结：LIGHT, also known as TNFSF14 or CD258, is a newly identified member of the TNF superfamily (TNFSF14) that is expressed by activated T lymphocytes, monocytes, granulocytes, spleen cells, and immature dendritic cells. TNFSF14 / LIGHT / CD258 is a type II transmembrane protein that is known to bind 2 membrane-bound TNFSF signaling receptors: HVEM, which is predominantly expressed by T cells, and lymphotoxin β receptor (LTβR), which is expressed by stromal cells and nonlymphoid hematopoietic cells. TNFSF14 / LIGHT / CD258 also binds to a soluble non-signaling receptor, decoy receptor 3 (DcR3), which can modulate the function of LIGHT in vivo. TNFSF14 / LIGHT / CD258 can also costimulate T cell responses via HVEM, which is constitutively expressed in most lymphocyte subpopulations, including CD4and CDT cells. In addition, TNFSF14 / LIGHT / CD258 has been shown to suppress tumor formation in vivo and to induce tumor cell apoptosis via the up-regulation of intercellular adhesion molecule 1 and an increased lymphocyte adhesion to cancer cells. Thus, TNFSF14 / LIGHT / CD258 is being actively investigated as a possible basis for cancer treatment.
形式：Lyophilized
纯度：> 90 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.5. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：CD258 Protein, Human; HVEML Protein, Human; LIGHT Protein, Human; LTg Protein, Human; TR2 Protein, Human
性质：
表达系统：HEK293 Cells
种属：Human
氨基酸序：Asp74-Val240
标签类型：N-rFc
分子量：The recombinant human TNFSF14 consists of 418 amino acids and predicts a molecular mass of 45.7 kDa.
活性：Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC). The EDfor this effect is typically 5-25 ng/mL.
内毒素：< 1.0 EU per μg protein as determined by the LAL method.
基因名称：tumor necrosis factor (ligand) superfamily, member 14
通用名：TNFSF14
蛋白序参考：AAK26160.1
总结：LIGHT, also known as TNFSF14 or CD258, is a newly identified member of the TNF superfamily (TNFSF14) that is expressed by activated T lymphocytes, monocytes, granulocytes, spleen cells, and immature dendritic cells. TNFSF14 / LIGHT / CD258 is a type II transmembrane protein that is known to bind 2 membrane-bound TNFSF signaling receptors: HVEM, which is predominantly expressed by T cells, and lymphotoxin β receptor (LTβR), which is expressed by stromal cells and nonlymphoid hematopoietic cells. TNFSF14 / LIGHT / CD258 also binds to a soluble non-signaling receptor, decoy receptor 3 (DcR3), which can modulate the function of LIGHT in vivo. TNFSF14 / LIGHT / CD258 can also costimulate T cell responses via HVEM, which is constitutively expressed in most lymphocyte subpopulations, including CD4and CDT cells. In addition, TNFSF14 / LIGHT / CD258 has been shown to suppress tumor formation in vivo and to induce tumor cell apoptosis via the up-regulation of intercellular adhesion molecule 1 and an increased lymphocyte adhesion to cancer cells. Thus, TNFSF14 / LIGHT / CD258 is being actively investigated as a possible basis for cancer treatment.
形式：Lyophilized
纯度：> 90 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.5. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：CD258 Protein, Human; HVEML Protein, Human; LIGHT Protein, Human; LTg Protein, Human; TR2 Protein, Human
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LIGHT Protein, Human, Recombinant (rFc Tag)
$3475
