- $2565
- Leading Biology
- 美国
- PH50587E1
- 2025年07月14日
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- 详细信息
- 技术资料
- 保存条件：
Stable for 1 year at -607°C or below from date of shipment.
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 规格：
50 ug
蛋白长度：A DNA sequence encoding the human PKLR (NP_000289.1) (Leu47-Ser574) was expressed with a polyhistidine tag at the N-terminus.
性质：
表达系统：E. coli
种属：Human
氨基酸序：Leu47-Ser574
标签类型：N-His
分子量：The recombinant human PKLR consists of 546 amino acids and predicts a molecular mass of 59.1 KDa. It migrates as an approximately 53-60 KDa band in SDS-PAGE under reducing conditions.
活性：Kinase activity untested
内毒素：Please contact us for more information.
基因名称：pyruvate kinase, liver and RBC
通用名：PKLR
蛋白序参考：NP_000289.1
总结：Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variable severity. PKLR expression was increased in liver metastases as well as in primary colorectal tumors of patients with metastatic disease. PKLR protein variants may affect the frequency, and the intensity of malaria episodes induced by different Plasmodium parasites in humans living in areas of endemic malaria.
形式：Liquid
纯度：> 85 % as determined by SDS-PAGE.
储存条件：Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Supplied as sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
别名：PK1 Protein, Human; PKL Protein, Human; PKR Protein, Human; PKRL Protein, Human; RPK Protein, Human
性质：
表达系统：E. coli
种属：Human
氨基酸序：Leu47-Ser574
标签类型：N-His
分子量：The recombinant human PKLR consists of 546 amino acids and predicts a molecular mass of 59.1 KDa. It migrates as an approximately 53-60 KDa band in SDS-PAGE under reducing conditions.
活性：Kinase activity untested
内毒素：Please contact us for more information.
基因名称：pyruvate kinase, liver and RBC
通用名：PKLR
蛋白序参考：NP_000289.1
总结：Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variable severity. PKLR expression was increased in liver metastases as well as in primary colorectal tumors of patients with metastatic disease. PKLR protein variants may affect the frequency, and the intensity of malaria episodes induced by different Plasmodium parasites in humans living in areas of endemic malaria.
形式：Liquid
纯度：> 85 % as determined by SDS-PAGE.
储存条件：Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Supplied as sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
别名：PK1 Protein, Human; PKL Protein, Human; PKR Protein, Human; PKRL Protein, Human; RPK Protein, Human
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PKLR Protein, Human, Recombinant (His Tag)
$2565
