BCMA Protein, Human, Recombina

蛋白长度：A DNA sequence encoding the human TNFRSF17 (NP_001183.2) (Met1-Ala54) was expressed with a polyhistidine tag at the C-terminus.

性质：

表达系统：HEK293 Cells

种属：Human

氨基酸序：Met1-Ala54

标签类型：C-His

分子量：The recombinant human TNFRSF17 consists of 65 amino acids and predicts a molecular mass of 7.3 kDa. As a result of glycosylation, It migrates as an approximately 16.9 and 12.4 KDa band in SDS-PAGE under reducing conditions.

活性：1. Immobilized Human BAFF (Cat:PH50377M3) at 2μg/mL (100 μl/well) can bind Human BCMA (Cat:PH50469M2), The ECof Human BCMA (Cat:PH50469M2) is 30-80 ng/mL. 2. Immobilized Mouse TNFSF13(Cat:50965-M01H) at 2μg/mL (100 μl/well) can bind Human BCMA (Cat:PH50469M2), The ECof Human BCMA (Cat:PH50469M2) is 0.6-2.1 ng/mL.

内毒素：< 1.0 EU per μg protein as determined by the LAL method.

基因名称：tumor necrosis factor receptor superfamily member 17

通用名：TNFRSF17

蛋白序参考：NP_001183.2

总结：Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.

形式：Lyophilized

纯度：> 95 % as determined by SDS-PAGE.

储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

别名：BCM Protein, Human; BCMA Protein, Human; CD269 Protein, Human; TNFRSF13A Protein, Human