- $15000
- Leading Biology
- 美国
- PH50230M4
- 2025年07月15日
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- 详细信息
- 技术资料
- 保存条件：
Stable for 1 year at -250°C or below from date of shipment.
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 规格：
1 mg
蛋白长度：A DNA sequence encoding the human IL17BR (NP_061195.2) (Met1-Gly289) was expressed with the Fc region of human IgG1 at the C-terminus.
性质：
表达系统：HEK293 Cells
种属：Human
氨基酸序：Met1-Gly289
标签类型：C-hFc
分子量：The recombinant human IL17BR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 513 amino acids and has a predicted molecular mass of 56.9 kDa. The apparent molecular mass of the protein is approximately 67 kDa in SDS-PAGE under reducing conditions.
活性：1. Measured by its binding ability in a functional ELISA. 2. Immobilized human IL17BR-Fc at 10μg/mL (100μL/well) can bind biotinylated human Fc-IL25 (Cat:PH50452M3).The ECof human Fc-IL25 (Cat:PH50452M3) is 4.5-10.4ng/mL.
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.
基因名称：interleukin 17 receptor B
通用名：IL17RB
蛋白序参考：NP_061195.2
总结：IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation of the Bcl-2. IL17RB may be the only gene expressed in CD4+ T cells whose transcript measurement is correlated with the variation in IgE level in asthmatics. Diseases associated with IL17RB include Chronic Mucocutaneous Candidiasis and Seborrheic Infantile Dermatitis.
形式：Lyophilized
纯度：> 85 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：CRL4 Protein, Human; EVI27 Protein, Human; IL17BR Protein, Human; IL17RH1 Protein, Human
性质：
表达系统：HEK293 Cells
种属：Human
氨基酸序：Met1-Gly289
标签类型：C-hFc
分子量：The recombinant human IL17BR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 513 amino acids and has a predicted molecular mass of 56.9 kDa. The apparent molecular mass of the protein is approximately 67 kDa in SDS-PAGE under reducing conditions.
活性：1. Measured by its binding ability in a functional ELISA. 2. Immobilized human IL17BR-Fc at 10μg/mL (100μL/well) can bind biotinylated human Fc-IL25 (Cat:PH50452M3).The ECof human Fc-IL25 (Cat:PH50452M3) is 4.5-10.4ng/mL.
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.
基因名称：interleukin 17 receptor B
通用名：IL17RB
蛋白序参考：NP_061195.2
总结：IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation of the Bcl-2. IL17RB may be the only gene expressed in CD4+ T cells whose transcript measurement is correlated with the variation in IgE level in asthmatics. Diseases associated with IL17RB include Chronic Mucocutaneous Candidiasis and Seborrheic Infantile Dermatitis.
形式：Lyophilized
纯度：> 85 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：CRL4 Protein, Human; EVI27 Protein, Human; IL17BR Protein, Human; IL17RH1 Protein, Human
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IL17RB Protein, Human, Recombinant (hFc Tag)
$15000
