Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
形态:
Liquid
亚型:
IgG
免疫原:
Synthetic peptide within Human IGJ aa 50-150 (internal sequence).
规格:
50μl/100μl
规格:
50μl
产品价格:
¥1500.0
规格:
100μl
产品价格:
¥2500.0
A J chain is a protein component of the antibodies IgM and IgA. It is a 137 residue polypeptide, encoded by the IGJ gene. The J Chain is required for IgM or IgA to be secreted into mucosa. As part of a polymeric immunoglobulin (pIg), the J-chain is essential for binding of pIg to the pIgR, which forms the secretory component upon excretion of the secretory pIg by epithelial cells. This binding facilitates transport of the J-chain positive pIg molecules from the basal to the apical sides of epithelial cells. Because IgM and IgA are the only two types of antibody that polymerize, initial hypotheses stated that J chain was required for polymerization. However, it was subsequently found that IgM is able to polymerize in the absence of J chain as both a pentamer and a hexamer, however, both of these exist to lesser numbers in organisms lacking J chains. In such cases, there are also fewer IgA dimers. The J-chain also plays a role in the activation of complement. J-chain negative IgM hexamers are 15-20 times more effective at activating complement than J-chain positive IgM pentamers. A consequence of this lack of complement activation is it allows J-chain positive pIgM to bind antigens without causing excessive damage to epithelial membranes through complement activation.