Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
形态:
Liquid
亚型:
IgG
免疫原:
Recombinant protein within Human CAMKIV aa 360-473 / 473.
规格:
50μl/100μl
规格:
50μl
产品价格:
¥1500.0
规格:
100μl
产品价格:
¥2500.0
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory Threonine residue at position 177.