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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
999
- 靶点:
Ikaros
- 级别:
Ikaros Antibody
- 目录编号:
Ikaros Antibody
- 克隆性:
单克隆
- 抗原来源:
小鼠
- 保质期:
Ikaros Antibody
- 抗体英文名:
anti-mouse Ikaros Antibody-PE
- 抗体名:
Ikaros Antibody
- 标记物:
PE
- 宿主:
小鼠
- 适应物种:
小鼠
- 免疫原:
Ikaros Antibody
- 亚型:
Ikaros Antibody
- 形态:
Ikaros Antibody
- 应用范围:
ICFC
- 保存条件:
2-8℃
- 浓度:
0.2 mg/ml
- 规格:
25 µg/100 µg
| 规格: | 25 µg | 产品价格: | ¥2700.0 |
|---|---|---|---|
| 规格: | 100 µg | 产品价格: | ¥6300.0 |
Description :Ikaros family members, including Ikaros and Helios, play a role in the development oflymphocytes and B and T cells. They are nuclear factors that colocalize with DNA replicationmachinery components in higher-order chromatin structures and respond to signaling events,such as T cell activation. Helios and Ikaros bind to similar DNA sequences, and they functionas hemopoietic-specific transcription factors. Members of the Ikaros family contain zinc-fingerdomains that are involved in DNA-binding and in the formation of homodimers andheterodimers between Ikaros family members. Expression of Ikaros is primarily detected in thethymus and spleen, where it is essential for regulating T cell specific gene transcription and forthe differentiation and commitment of early hemopoietic progenitors to the B and T lymphoidlineages. Ikaros and Helios also appear to regulate cell cycle entry by inducing transcriptionalrepression under varying conditions and, thereby, mediate T cell activation and IL-2 mediatedsignaling events.
Verified Reactivity :Mouse
Antibody Type :Monoclonal
Host Species :Mouse
Immunogen :N-terminal half of mouse Ikaros fused to GST.
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation :The antibody was purified by affinity chromatography and conjugated with PE under optimalconditions.
Concentration :0.2 mg/ml
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application :ICFC - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by intracellular immunofluorescent staining withflow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.015µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimalperformance for each application.
Excitation Laser :Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)
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文献和实验1. Cobb SB, et al. 2000. Genes & Dev. 14:2146. (IF)
2. Hahm K. et al. 1998. Genes Dev. 12:782. (IP)
3. Andricovich J, et al. 2016. J. Clin. Invest. 126:905. (ICFC) Pubmed
Product Citations:
1. Fistonich C, et al. 2018. J Exp Med. 215:2586. PubMed
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