分子信息
概述
IL6 分子靶点信息概述
分子名:IL6, interleukin 6
基因家族:Interferons; Interleukins; Interleukin 6 type cytokine family
别名:IL-6; BSF2; HGF; HSF
曾用名:IFNB2
全称:interferon, beta 2; interleukin 6 (interferon, beta 2)
IL6 分子靶点综述
白细胞介素6(IL-6)是一种同时具备促炎性和抗炎性的细胞因子。在人类中,它由IL-6基因编码。在感染期间和受到外伤后,尤其是烧伤或其它组织损伤导致的炎症,IL-6会由T细胞和巨噬细胞分泌,促进免疫应答。研究表明,小鼠抵抗肺炎链球菌感染时需要IL-6的参与,说明IL-6在抵抗感染中发挥作用。IL-6在很多疾病如糖尿病、动脉粥样硬化、抑郁症、阿尔茨海默氏病、系统性红斑狼疮、多发性骨髓瘤、前列腺癌、白塞氏病和类风湿性关节炎等中可促进炎性和自身免疫疾病进程。晚期/转移性癌症患者的血液中具有较高水平的IL-6。
小鼠 IL6, IL-6, IFNB2, HGF 靶点信息
小鼠 Mouse Il6 分子靶点信息
分子名:Il6, interleukin 6
别称:
Il-6
基因序列:NCBI_Gene: 16193
蛋白序列:
UniprotKB: P08505
UniprotKB: A0A0G2JFG1
UniprotKB: A0A0G2JFT1
UniprotKB: A0A0G2JGF4
UniprotKB: A2RTD1
UniprotKB: Q0PMN1
UniprotKB: Q3U8J8
小鼠 Mouse Il6 靶点分子功能(预测)
Enables cytokine activity and interleukin-6 receptor binding activity. Involved in several processes, including animal organ development; positive regulation of macromolecule metabolic process; and regulation of peptide hormone secretion. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including cellular response to cytokine stimulus; regulation of gene expression; and salivary gland morphogenesis. Located in external side of plasma membrane and extracellular space. Part of interleukin-6 receptor complex. Is expressed in several structures, including adrenal gland; genitourinary system; gut; liver; and thymus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6).