Store at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.1% Proclin300,0.2% BSA,pH7.2.
规格:
100 T/100 T/100 T
规格:
100 T
产品价格:
¥2900.0
规格:
100 T
产品价格:
¥1990.0
规格:
100 T
产品价格:
¥1780.0
产品名称:PE-Cy7 Mouse anti-Human CD19 mAb 货号:A22819 背景:This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. 别名:B4; CVID3 宿主:Mouse 反应物种:Human 验证应用:FC 免疫原:Recombinant protein of human CD19. 基因ID:930 存储缓冲液:Store at 4℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.1% Proclin300,0.2% BSA,pH7.2.