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RT/2-8℃/-20℃
3年
Carbendazim
999
北京康瑞纳生物科技有限公司
10605-21-7
5g/25g/100g
规格: | 5g | 产品价格: | ¥60.0 |
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规格: | 25g | 产品价格: | ¥120.0 |
规格: | 100g | 产品价格: | ¥210.0 |
多菌灵 10605-21-7 多菌灵 10605-21-7
产品名称:多菌灵 10605-21-7
产品编号:A1445
中文别称 多菌灵
英文别称 Carbendazim
CAS 10605-21-7
分子式 C9H9N3O2
分子量 191.19
储存条件 RT
有效期 2年
级别 BR
溶解性 50 mg/mL in 1N HCl
来源 化学合成
纯度 ≥99%
性状 白色粉末
包装 瓶
规格 25g
描述 是一种广谱的苯并咪唑类抗菌化合物。(It is a broad-spectrum benzimidazole antibacterial compound.)
靶点 Fungal
通路 Anti-infection
生物活性 Carbendazim (Mercarzole, Carbendazole) is a broad-spectrum systemic antimycotic and can be used to control a broad range of diseases on field crops, fruits, and vegetables, including sclerotinia rot of canola, wheat head blight, peanut leaf spot, and SB on rice. Its mode of action is to inhibit the formation of mitotic microtubules in of fungi.[1-2]
In Vitro Carbendazim (me.thyl 2-benzimidazolecarbamate) is widely used as a systemic fungicide in human food production and appears to act on fungal tubulin. However, it also inhibits proliferation of human cancer cells, including drug- and multidrug-resistant and p53-deficient cell lines, including murine melanoma, human breast, ovarian, lung, leukemia, and colon carcinoma cell lines, arresting the cells at the G2/M phase of the cell cycle and inducing apoptosis. It inhibits the proliferation of MCF7 human breast cancer cells with IC50 of 10 μM and arrests mitosis at a similar concentration (8 μM), in concert with suppression of microtubule dynamic instability without appreciable microtubule depolymerization. With microtubules assembled in vitro from pure tubulin, carbendazim also suppresses dynamic instability, reducing the dynamicity by 50% at 10 μM, with only minimal (21%) reduction of polymer mass. Carbendazim binds to mammalian tubulin (Kd, 42.8 ± 4.0 μM)[1].
In Vivo Carbendazim (CBZ) is active in vivo against human pancreatic, lung, prostate, colon, and breast tumor xenografts. Oral administrations with CBZ at 100 and 500?mg/kg body weight for 28 days induces hepatic lipid metabolism disorder which is characterized by significant increases of hepatic lipid accumulation and triglyceride (TG) levels in mice. The serum cholesterol (TC), high-density lipoprotein, and low-density lipoprotein levels also increase after CBZ exposure. CBZ may also induce the occuring of inflammation characterized by the increase of serum IL-1β and IL-6 levels[2].
细胞实验 MCF7/GFP cells seeded at 3 × 104 cells/ml in six-well plates are allowed to adhere (24 h), after which the medium is replaced with medium containing carbendazim. Cells are incubated with a range of carbendazim concentrations (0.5-50 μM) for 24 h, rinsed with Versene (137 mM NaCl, 2.7 mM KCl, 1.5 mM KH2PO4, 8.1 mM Na2HPO4, 0.5 mM EDTA, pH 7.2), and detached with trypsin in Versene. Both adherent and floating cells are collected. For determination of cell proliferation, cells are stained with trypan blue and counted by hemacytometer.[1]
动物实验 Carbendazim (oral gavage; 100 and 500 mg/kg; once daily in diet; 28 days) induces hepatic lipid metabolism disorder, it results in a significant increase of hepatic lipid accumulation and triglyceride (TG) levels in mice[2].
实验参考图
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Ren L, Liu J, Liu C, Yang T, Wu X, Zhang X, Yang L, Xia J, Li W. AIn Vitro Cell(RAW264.7 cells;100 ng/mL LPS,24 h at 37 °C) RAW264.7 cells were seeded in confocal dishes at a density of 1 × 105 cells per dish. After the culture of 24 h, cells were treated with 100 ng/mL LPS in different media, including a control medium, PACDFe extract, and PACDFe hydrogel extract supplemented with 1 μM LL-37 for another 24 h at 2136 °C. 更多文献信息请详询客服
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