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- 保存条件：
RT/2-8℃/-20℃
- 保质期：
3年
- 英文名：
Guanidine hydrochloride
- 库存：
999
- 供应商：
北京康瑞纳生物科技有限公司
- CAS号：
50-01-1
- 规格：
100g
盐酸胍 50-01-1 盐酸胍 50-01-1
产品名称：盐酸胍 50-01-1
产品编号：A2059
中文别称 盐酸亚氨脲；Aminoformamidine hydrochloride； Aminomethanamidine hydrochloride；Guanidinium chloride
英文别称 Guanidine HCl
CAS 50-01-1
分子式 CH5N3· HCl
分子量 95.53
储存条件 RT
有效期 2年
溶解性 solubility(6M in water,20℃)
危险代码 22-36/38
纯度 Purity ≥99%
性状 白色结晶粉末
包装 瓶
规格 100g 500g 5kg 25KG
盐酸胍生物学应用：
（1）作为蛋白质变性剂，可以溶解一些不溶的或变性蛋白质，例如内涵体；也可用于活性蛋白或酶的初始折叠。
（2） 作为提取细胞总RNA实验中的强烈变性剂。盐酸胍溶液可溶解蛋白质，导致细胞结构破坏，核蛋白二级结构破坏，从核酸上解离下来。还能够充分抑制细胞和整个组织的核糖核酸酶活性。 由于其生物学上的破坏特性，常称含有盐酸胍或者硫qing酸胍的缓冲液为离液缓冲液。
盐酸胍贮存条件：室温阴凉干燥保存；
盐酸胍急性毒性：有毒，小鼠腹腔半数致死量500mg/kg。有刺激性。
盐酸胍注意事项：盐酸胍有毒，使用时要小心做好个体防护。
盐酸胍在储存时可能会结块。它可能表现为自由流动的结晶粉末
具有分散在各处的固体材料的自由流动的粉末或固体。
产品的质量确实似乎没有受到影响，并且出现了由自由流动的块状盐酸胍制备的溶液完全相同的盐酸胍用于分离RNA，将核蛋白解离成其核酸蛋白质部分。
它是核糖核酸酶的抑制剂。
使用高浓度（6-8M）盐酸胍溶液使天然球状蛋白变性。
它显然破坏了蛋白质的氢键独特的结构。
然而，也有证据表明盐酸胍可能破坏通过提高疏水性残基在水溶液中的溶解度来实现疏水性相互作用。
准备说明：
为了在水中制备8M溶液，必须将溶液加热至35ºC约30分钟室温下盐酸胍在水中的最大溶解度为大约6M。
储存/稳定性
在室温下储存产品。应每六年对其在用户中的适用性进行一次重新评估
注意事项和免责声明：
仅供实验室使用。不用于药物、家庭或其他用途。
Guanidine hydrochloride 50-01-1
Product name: Guanidine hydrochloride 50-01-1
Product number: A2059
Also known in Chinese as urea hydrochloride; Aminoformamidine hydrochloride; Aminom.ethylamine hydrochloride; Guanidinium chloride
Also known as Guanidine HCl in English
CAS 50-01-1
Molecular formula CH5N3 · HCl
Molecular weight 95.53
Storage conditions RT
Validity period of 2 years
Solubility (6M in water, 20 ℃)
Hazard codes 22-36/38
Purity ≥ 99%
Appearance: White crystalline powder
Packaging bottle
Specification 100g 500g 5kg 25KG
Biological application of guanidine hydrochloride:
(1) As a protein denaturant, it can dissolve some insoluble or denatured proteins, such as endosomes; It can also be used for the initial folding of active proteins or enzymes.
(2) As a strong denaturant in the experiment of extracting total RNA from cells. Guanidine hydrochloride solution can dissolve proteins, causing damage to cell structure and secondary structure of nuclear proteins, leading to dissociation from nucleic acids. It can also fully inhibit the ribonuclease activity of cells and the entire tissue. Due to its biological destructive properties, buffer solutions containing guanidine hydrochloride or guanidine thiosulfate are often referred to as release buffer solutions.
Storage conditions for guanidine hydrochloride: Store at room temperature in a cool, dry place;
Acute toxicity of guanidine hydrochloride: toxic, with a median lethal dose of 500mg/kg in the abdominal cavity of mice. It is stimulating.
Precautions for guanidine hydrochloride: Guanidine hydrochloride is toxic, so be careful and take personal protective measures when using it.
Guanidine hydrochloride may clump during storage. It may manifest as a freely flowing crystalline powder
A free flowing powder or solid with solid materials dispersed throughout.
The quality of the product does not seem to have been affected, and a completely identical solution of guanidine hydrochloride prepared from freely flowing blocky guanidine hydrochloride has been used to separate RNA, dissociating the nucleoprotein into its nucleic acid protein portion.
It is an inhibitor of ribonuclease.
Use high concentration (6-8M) guanidine hydrochloride solution to denature natural globular proteins.
It clearly disrupts the unique hydrogen bonding structure of proteins.
However, there is also evidence to suggest that guanidine hydrochloride may disrupt hydrophobic interactions by increasing the solubility of hydrophobic residues in aqueous solutions.
Preparation instructions:
In order to prepare an 8M solution in water, the solution must be heated to 35 º C for approximately 30 minutes. At room temperature, the maximum solubility of guanidine hydrochloride in water is approximately 6M.
Storage/Stability
Store the product at room temperature. It should be reassessed for applicability among users every six years
Notes and Disclaimer:
For laboratory use only. Not used for medication, household or other purposes.
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文献和实验Ren L, Liu J, Liu C, Yang T, Wu X, Zhang X, Yang L, Xia J, Li W. AIn Vitro Cell（RAW264.7 cells；100 ng/mL LPS，24 h at 37 °C） RAW264.7 cells were seeded in confocal dishes at a density of 1 × 105 cells per dish. After the culture of 24 h, cells were treated with 100 ng/mL LPS in different media, including a control medium, PACDFe extract, and PACDFe hydrogel extract supplemented with 1 μM LL-37 for another 24 h at 1486 °C. 更多文献信息请详询客服
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