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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
999
- 靶点:
CD314 (NKG2D)
- 级别:
CD314 (NKG2D) Antibody
- 目录编号:
CD314 (NKG2D) Antibody
- 克隆性:
单克隆
- 抗原来源:
小鼠
- 保质期:
CD314 (NKG2D) Antibody
- 抗体英文名:
Cyanine5.5 anti-human CD314 (NKG2D) Antibody/PerCP
- 抗体名:
CD314 (NKG2D) Antibody
- 标记物:
PerCP
- 宿主:
小鼠
- 适应物种:
人
- 免疫原:
CD314 (NKG2D) Antibody
- 亚型:
CD314 (NKG2D) Antibody
- 形态:
CD314 (NKG2D) Antibody
- 应用范围:
FC
- 保存条件:
2-8℃
- 浓度:
CD314 (NKG2D) Antibody
- 规格:
25 tests/100 tests
| 规格: | 25 tests | 产品价格: | ¥2300.0 |
|---|---|---|---|
| 规格: | 100 tests | 产品价格: | ¥5900.0 |
Description :CD314 is a homodimeric C-type lectin-like protein also known as NKG2D. It is expressed on NKcells, CD8 T cells, γ/δ T cells, and in vitro induced LAK cells. Several molecules have beenidentified as the ligands for NKG2D, including MHC class-I chain-related protein A (MICA),MICB, and UL16-binding proteins (ULBPs). NKG2D has no intrinsic signaling capacity, butattains this by non-covalent association with DAP10 or DAP12 adaptors. In addition to being aprimary activation receptor on NK cells, NKG2D is also a costimulatory receptor for TCRmediated T cell proliferation and cytokine production. The interaction of NKG2D with its ligandsplays a role in the immune surveillance against pathogen and tumor cells, and in thepathogenesis of autoimmune diseases.
Verified Reactivity :Human
Reported Reactivity :African Green, Baboon, Cynomolgus, Rhesus
Antibody Type :Monoclonal
Host Species :Mouse
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation :The antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5under optimal conditions.
Concentration :Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application :FC - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.
* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm
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文献和实验1. Wu J, et al. 1999. Science 285:730.
2. Wu J, et al. 2000. J. Exp. Med. 192:1059.
3. Groh V, et al. 2001. Nature Immunol. 2:255.
4. Wu J, et al. 2002. J. Immunol. 169:1236.
5. Roberts A, et al. 2001. J. Immunol. 167:5527.
6. Groh V, et al. 2003. Proc. Natl. Acad. Sci. USA 100:9452.
7. Kraetzel K et al. 2008. Eur. Respir. J. 32:563. PubMed
8. Correia DV, et al. 2011. Blood 118:992. (FC) PubMed
9. Watanbe M, et al. 2014. Int Immunol. PubMed
Product Citations:
1. Cluff E, et al. 2022. Cancer Immunol Immunother. . PubMed
2. Ferry GM, et al. 2022. Front Immunol. 13:863155. PubMed
3. Veluchamy JP, et al. 2017. Sci Rep. 7:43873. PubMed
4. Ruth JH, et al. 2021. JCI Insight. 6:e145662. PubMed
5. Wiedemann A, et al. 2020. Nat Commun. 3.048611111. PubMed
6. Portillo AL, et al. 2021. iScience. 24(6):102619. PubMed
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