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文献和实验Screening for P-Glycoprotein (Pgp) Substrates and Inhibitors
P-glycoprotein (P-gp), the product of the human ABCB1 gene and often called MDR1, is the best understood membrane protein known to be involved in the active transport of drugs across biological membranes. In addition to mediating or limiting
Monitoring Recombinant Glycoprotein Heterogeneity
recombinant protein in vivo (1 ). Glycosylation is the most extensive source of protein heterogeneity, and many recent developments in analytical biotechnology have enhanced the ability to monitor and structurally define changes in oligosaccharides associated
Measurement of P-glycoprotein Function
The MDR 1-encoded P-glycoprotein (Pgp), when overexpressed in tumor cells, confers resistance to many clinically important classes of anticancer drugs. This phenomenon is called multidrug resistance (MDR). The finding that this gene
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