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文献和实验Genetic and Pharmacologic Models for Type 1 Diabetes
Figure 1. Histologic appearance of pancreatic islets in 5‐ to 6‐week‐old C57BL/6 wild‐type control (+/+) and heterozygous Ins2 Akita mice of both sexes. Insulin‐containing beta cells are stained
Structure-Based and Property-Compliant Library Design of 11-HSD1 Adamantyl Amide Inhibitors
for facilitating and streamlining this iterative design process. This chapter discloses an actual library design scenario for following up a lead compound that inhibits 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme. The application of computational
, regulates 17beta-hydroxysteroid dehydrogenase type 1 activity and expression in cultured rat granulosa cells.J Steroid Biochem Mol Biol, Jul 2000,73(5):203-10.3.Synergistic effects of activin and FSH on hyperphosphorylation of Rb and G1/S transition in rat
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