Purified 抗 TPX2 抗体

Purified anti-TPX2 Antibody详细如下：

Description ：The TPX2 protein, also known as targeting protein for Xklp1, restricted expression proliferationassociated protein p100, and differentially expressed in cancer and non-cancerous lung cellsprotein 2 (DIL2), is a 100 kD nuclear protein that contains two coiled-coil domains. The TPX2protein is strictly associated with spindle pole and mitotic spindle during mitosis. In the G2/Sposition of the cell cycle, TPX2 is diffusely distributed throughout nucleus. TPX2 has beenshown to be highly expressed in lung carcinomas cell lines, but not in normal lung tissues.TPX2 is thought to be required for the Ran-GTP dependent assembly of microtubules aroundchromosomes required to generate stable bipolar spindle with overlapping anti-parallelmicrotubule arrays and may also be involved in targeting Aurora-A kinase to the mitoticspindle. TPX2 has been shown to interact with a large number of proteins includingserine/threonine protein kinase 6, ribosomal protein 6, Bop-1, α-tubulin, and nucleolin amongothers. TPX2 can be modified by phosphorylation on serine 738. The 18D5 monoclonalantibody recognizes human TPX2 and has been shown to be useful for Western blotting.

Verified Reactivity ：Human

Antibody Type ：Monoclonal

Host Species ：Mouse

Immunogen ：Amino Acid: 1-220 of human TPX2

Formulation ：This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azideat 0.5 mg/ml.

Preparation ：The antibody was purified by affinity chromatography.

Concentration ：0.5 mg/ml

Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.

Application ：WB - Quality tested、ICC - Reported in the literature, not verified in house

Recommended Usage ：Each lot of this antibody is quality control tested by Western blotting. For Western blotting, thesuggested use of this reagent is 0.2 - 1.0 µg per ml. It is recommended that the reagent be titratedfor optimal performance for each application.