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文献和实验A Nested RT-PCR Assay to Detect BCR/abl
) (1 ). In this chromosomal translocation, exons from a major breakpoint cluster region (M-bcr), located on chromosome 22q11, are joined to the c-abl protooncogene, located on chromosome 9q34. When this chromosomal translocation occurs in a hematopoietic stem cell
A Nested Reverse Transcription-Polymerase Chain Reaction Assay to Detect BCR/abl
) (1) . In this chromosomal translocation, exons from a major breakpoint cluster region (M-bcr), located on chromosome 22q11, are joined to the c-abl proto-oncogene, located on chromosome 9q34. When this chromosomal translocation occurs in a hematopoietic stem cell
LDI-PCR: Identification of Known and Unknown Gene Fusions of the Human MLL Gene
-end of MLL , all recombination events occur in a small genomic region flanked by MLL exons 8–14, designated as the MLL breakpoint cluster region. Efforts from different laboratories, including our own, have led to the identification of more than 50 MLL
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