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机制有助于为早期发现肿瘤转移提供生物标志物，为干涉转移提供新策略，从而取得更好的预后。代谢失调是癌症的标志，癌基因和肿瘤抑制基因的突变会引起多种细胞内信号通路的改变，使肿瘤细胞重新设计以提高生存和生长力。独特的生物化学微环境进一步影响肿瘤细胞代谢表型，进而影响肿瘤的进展、对治疗的反应和患者的预后。本研究揭示了UDP-glucose对肿瘤转移的独特影响，提出了代谢物调节蛋白功能的新模型，建立了代谢与RNA稳定性之间的新关联。实验结果表明，经过表皮生长因子受体（EGFR）活化，磷酸化的UGDH与HuR相互