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文献和实验Models of Polycystic Kidney Disease
Polycystic kidney disease (PKD) is a potentially life-threatening disorder that affects both adult and pediatric patients. PKD can be either inherited as a dominant (ADPKD) or a recessive trait (ARPKD) or acquired. The disease
The TRPP Signaling Module: TRPP2/Polycystin-1 and TRPP2/PKD1L1
overexpression to establish molecular interdependencies. Canonical and noncanonical Wnt signaling have been associated with polycystic kidney disease. Furthermore, PRKCSH and SEC63 have been implicated in TRPP/polycystin protein maturation. Putative targets
that target human and mouse transforming growth-factor beta (TGF-β), as well as human polycystic kidney disease gene 1 (PKD1) and JC virus large T-antigen. The tetraloop modification of the sTRSV hairpin ribozyme is considered superior to designs based
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