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文献和实验Differential Expression of Apoptosis-Associated Genes bax and bcl-2 in Ovarian Cancer
either as inhibitors (e.g., bcl-2, bcl-xl, mcl- 1) or promoters (e.g., bcl-xs, bax, bak, bad) of apoptosis (1 -3 ). The chromosomal translocation t(14;18), leading to overexpression of the Bcl-2 protein was first described in human B-cell lymphoma (4 ). Later
like PKB. Proapoptotic proteins which can be phosphorylated and inhibited by PKB include BAD (BCL2 Antagonist of Cell Death), human Caspase9, and the forkhead family of transcription factors. PKB can also cause stimulation of NF-KappaB (Nuclear Factor-Kappa
The pSC101BADγβαA-I-SceI[amp] vector was assembled by PCR amplification of the I-SceI gene together with the Tet-Repressor, Tet-Promoter and ampicillin resistance gene sequences from the PsiI-digested pST98AS plasmid (AF170483 ) (16) [oligo
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