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文献和实验Specificity Profiling of Protein‐Binding Domains Using One‐Bead‐One‐Compound Peptide Libraries
against macromolecular targets. They have proven particularly useful in profiling the binding specificity of protein modular domains (e.g., SH2 domains, BIR domains, and PDZ domains); subsequently, the specificity information can be used to predict the protein targets
Detecting Low‐Affinity Extracellular Protein Interactions Using Protein Microarrays
, W.M., Wu, W., Andre, I., Qian, B., Baker, D., and Zipursky, S.L. 2007. A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Cell 130:1134‐1145.
-binding proteins. One of the features that make zinc-fingers ideal for protein engineering is their modular relationship with each other. Our next goal was to test whether the human zinc fingers isolated using our in vivo screening could function
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