- 询价
- Biomatik
- 美国
- EKU08927
- 2025年07月10日
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文献和实验Stability and Ubiquitination of the Tumor Suppressor Protein p53
The ubiquitin-dependent proteolysis pathway constitutes a major pathway in the cell for selective protein degradation. The covalent attachment of multiple ubiquitin molecules to lysine residues of a target protein serves to signal
Senescence Regulation by the p53 Protein Family
p53, a guardian of the genome, exerts its tumor suppression activity by regulating a large number of downstream targets involved in cell cycle arrest, DNA repair, apoptosis, and cellular senescence. Although p53-mediated apoptosis is able
The p53 protein (reviewed in refs. 1 –5 ) is a latent transcription factor that is activated in response to a variety of cellular stresses, including DNA damage, mitotic spindle damage, heat shock, hypoxia, cytokines, metabolic changes
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