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文献和实验alleles (homozygote). This procedure has been used to generate animals lacking either the plasma membrane dopamine transporter (DAT; Fig. 2 ) or the vesicular monoamine transporter (VMAT2; Fig. 3 ). Both DAT and VMAT2 are essential for dopamine homeostasis
Vesicular monoamine transporters (VMATs) are involved in the presynaptic packaging of monoaminergic neurotransmitters into storage granules. Upon an action potential, vesicles release their contents into the synaptic cleft via exocytosis
Immunochemical Analysis of Dopamine Transporters in Parkinson Disease
to dopamine or tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, have been used to identify these neurons. Recently, considerable attention has been given to the plasma membrane dopamine tranporter (DAT ) and the vesicular monoamine
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