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文献和实验Characterization of Cannabinoid Receptors
Breivogel, C.S. and Childers, S.R. 2000. Cannabinoid agonist signal transduction in rat brain: Comparison of cannabinoid agonists in receptor binding, G‐protein activation and adenylyl cyclase inhibition. J. Pharm. Exp. Therap. 295:328
receptor in the rat brain were determined. CMS induced gender-specific aversions, which were blocked by WIN55,212-2, a nonspecific CB1 and CB2 cannabinoid receptor agonist. Direct CB2 antisense oligonucleotide microinjection into the mouse brain induced
Overview of Receptor Allosterism
of the binding of the agonist, [3 H] N6 ‐cyclohexyladenosine ([3 H]CHA) by the modulator PD 81,723 at the A1 adenosine receptor in rat brain membranes. Data taken from Bruns and Fergus (). (C ) Simulations based on a model of concomitant orthosteric
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