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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
999
- 靶点:
CD207
- 级别:
anti-human CD207 (Langerin) Antibody
- 目录编号:
anti-human CD207 (Langerin) Antibody
- 克隆性:
单克隆
- 抗原来源:
小鼠
- 保质期:
anti-human CD207 (Langerin) Antibody
- 抗体英文名:
anti-human CD207 (Langerin) Antibody-PE
- 抗体名:
CD207 抗体
- 标记物:
PE
- 宿主:
小鼠
- 适应物种:
人
- 免疫原:
anti-human CD207 (Langerin) Antibody
- 亚型:
anti-human CD207 (Langerin) Antibody
- 形态:
anti-human CD207 (Langerin) Antibody
- 应用范围:
FC
- 保存条件:
2-8℃
- 浓度:
anti-human CD207 (Langerin) Antibody
- 规格:
25 tests
Description :CD207, also known as Langerin, is a 40 kD type II transmemberane cell glycoprotein whichbelongs to C-type lectin with mannose binding specificity. It is predominantly expressed onLangerhans cells and induces the formation of Birbeck granules, the Langerhans cell hallmarkorganelle. It is also found on several other subtypes of dendritic cells, such as dermal CD103-positive dendritic cells and splenic CD8-positive dendritic cells. Langerin is generally thought tobe involved in antigen processing. Recently, it has been found that HIV captured by Langerinwas internalized into Birbeck granule and degraded, which results in inhibition of HIV-1 infectionand subsequent transmission.
Verified Reactivity :Human
Reported Reactivity :Cynomolgus
Antibody Type :Monoclonal
Host Species :Mouse
Immunogen :Primary human Langerhans cells
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation :The antibody was purified by affinity chromatography and conjugated with PE under optimalconditions.
Concentration :Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application :FC - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser :Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)
Application Notes :Additional reported application (for the relevant formats) includes: blocking the binding of HIV-1 toLangerhans cells .
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文献和实验1. Witte LD, et al. 2007. Nat. Med. 13:367. (Block)
Product Citations:
1. Alcántara‐Hernández M et al. 2017. Immunity. 47(6):1037-1050 . PubMed
2. Cavrois M, et al. 2019. PLoS One. 14:e0221181. PubMed
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