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- 详细信息
- 文献和实验
- 技术资料
- 库存:
100
- 国食药监械注册号:
无
- 保修期:
12个月
- 现货状态:
30天
- 供应商:
玉研仪器公司
- 规格:
敬请来电咨询
电惊厥仪设计用来诱发研究动物惊厥。根据不同动物不同接触阻抗,反馈电路可自动调整电流水平,产生一致重复电流。
· 可预先测量动物的阻抗并显示,假如阻抗太大导致施加太大的预期电流,会有黄灯报警提示;
· 电惊厥仪标准配备有耳电极;
· 可根据需要选配角膜电极;
· 一个可选的双向单元盒可以安放在动物与电惊厥仪之间,间隔地反向脉波,这种情况下最大频率会变为100Hz。
控制面板:
电刺激仪是专为诱导动物的抽搐以用于研究,可以从电路与动物接触来调整阻抗的差异,反馈电路可以确保每次对动物刺激的一致性。
主要技术参数:
| 频率 | 1-299 pulses/sec. |
| 可调时间 | 0.1-9.9 sec. |
| 顺从电压 | 2.5 kV |
| 电流范围 | 1-99mA |
| 输出阻抗 | 0 Ohm to 25 kOhm |
| 脉冲宽度 | 0.1 - 0.9 ms. |
| 脉冲上升和下降时间 | 20 µs |
| LED 显示器 | 0 to 199 kOhm |
可根据需要,选择组织损毁仪:
组织损毁仪
· 恒定的电流能够确保测试结果有良好的重复性;
· 可用于药物对大脑皮层或大脑皮下层区域引起电休克进行精确测定;
· 持续的电流等级通过反馈电路形成,该电路还可调节不同动物间不同的阻抗;
· 动物阻抗能够被预测试和显示,并且在阻抗太高而不能发出理想的电流信号时,会自动警报提示。
型号:53500
控制面板:
可以使用标准的电极,也可根据实验人员的需要定制电极。有逆变器、双相单元、双极型逆变器可选。
主要技术参数:
| 电流范围 | 10µA-99 mA |
| 马克斯电极电阻 | 20 MO (10 µA) down- 2KO (100 mA) |
| 脉冲持续时间 | 1-99 sec. or manually controlled |
| 顺从电压 | 200V |
| 尺寸 | 25 x 15 x 11 cm |
定制型损毁电极:
型号:KD-IE
| 材质 | 100μm铂铱丝 |
| L1 | 30mm |
| d1 | 0.25mm |
| d | 100μm |
| L2 | 10mm |
| 阻抗 | <30kΩ(请备注) |
| 接头 | 0.8mm插针 |
敬请关注玉研仪器微信号

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文献和实验1、Shi H, Zhang X, Weng YL, et al. m6A facilitates hippocampus-dependent learning and memory through YTHDF1. Nature. 2018;563(7730):249-253. doi:10.1038/s41586-018-0666-1
2、Goldfarb S, Fainstein N, Ganz T, Vershkov D, Lachish M, Ben-Hur T. Electric neurostimulation regulates microglial activation via retinoic acid receptor α signaling. Brain Behav Immun. 2021;96:40-53. doi:10.1016/j.bbi.2021.05.007
3、Maynard KR, Hobbs JW, Rajpurohit SK, Martinowich K. Electroconvulsive seizures influence dendritic spine morphology and BDNF expression in a neuroendocrine model of depression. Brain Stimul. 2018;11(4):856-859. doi:10.1016/j.brs.2018.04.003
4、Goldfarb S, Fainstein N, Ben-Hur T. Electroconvulsive stimulation attenuates chronic neuroinflammation. JCI Insight. 2020;5(17):e137028. doi:10.1172/jci.insight.137028
5、Jonckheere J, Deloulme JC, Dall'Igna G, et al. Short- and long-term efficacy of electroconvulsive stimulation in animal models of depression: The essential role of neuronal survival. Brain Stimul. 2018;11(6):1336-1347. doi:10.1016/j.brs.2018.08.001
6、Ramnauth AD, Maynard KR, Kardian AS, et al. Induction of Bdnf from promoter I following electroconvulsive seizures contributes to structural plasticity in neurons of the piriform cortex. Brain Stimul. 2022;15(2):427-433. doi:10.1016/j.brs.2022.02.003
7、Tunc-Ozcan E, Brooker SM, Bonds JA, et al. Hippocampal BMP signaling as a common pathway for antidepressant action. Cell Mol Life Sci. 2021;79(1):31. doi:10.1007/s00018-021-04026-y
8、Nakamura-
Maruyama E, Kai R, Himi N, et al. Ryanodine receptors are involved in the improvement of depression-like behaviors through electroconvulsive shock in stressed mice. Brain Stimul. 2021;14(1):36-47. doi:10.1016/j.brs.2020.11.001
9、Chang AD, Vaidya PV, Retzbach EP, et al. Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures. Neuropsychopharmacology. 2018;43(5):1088-1098. doi:10.1038/np*p.2017.252
10、Zhang TR, Guilherme E, Kesici A, Ash AM, Vila-Rodriguez F, Snyder JS. Electroconvulsive Shock, but Not Transcranial Magnetic Stimulation, Transiently Elevates Cell Proliferation in the Adult Mouse Hippocampus. Cells. 2021;10(8):2090.doi:10.3390/cells10082090
11、Kobayashi K, Mikahara Y, Murata Y, et al. Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation. iScience. 2020;23(4):101025. doi:10.1016/j.isci.2020.101025
12、Baker EM, Thompson CH, Hawkins NA, et al. The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy. Epilepsia. 2018;59(6):1166-1176. doi:10.1111/epi.14196
13、Gonçalves CL, Abelaira HM, Rosa T, et al. Keta*mine treatment protects against oxidative damage and the immunological response induced by electroconvulsive therapy. Pharmacol Rep. 2021;73(2):525-535. doi:10.1007/s43440-020-00200-4
14、Alizadeh Makvandi A, Khalili M, Roghani M, Amiri Moghaddam S. Hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal BDNF and oxidative stress in a rat model of depression. J Chem Neuroanat. 2021;117:102001. doi:10.1016/j.jchemneu.2021.102001
15、Kim SH, Park HG, Jeong SH, Kang UG, Ahn YM, Kim YS. Electroconvulsive Seizure Alters the Expression and Daily Oscillation of Circadian Genes in the Rat Frontal Cortex. Psychiatry Investig. 2018;15(7):717-726. doi:10.30773/pi.2018.01.18.2
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