- 询价
- BPS Bioscience
- 美国
- 79043-1
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
room temp.
- 保质期：
Stable at -20°C for up to two years. The solubility of this compound in DMSO is > 19.2 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.
- 英文名：
EPZ015666
- 库存：
1
- 供应商：
BPS Bioscience Inc.
- CAS号：
/
- 规格：
5 mg
EPZ015666 is a potent, selective, competitive PRMT5 inhibitor (IC50 = 22 nM). EPZ015666 exhibits >10,000-fold specificity for PRMT5 vs. other methyltransferases. EPZ015666 blocks the association of PRMT5 with methylosome protein 50 (WDR77), which is necessary to form an active methyltransferase complex. Treatment of MCL cell lines with nM concentrations of EPZ015666 leads to inhibition of SmD3 methylation and cell death."
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EPZ015666
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