- 询价
- BPS Bioscience
- 美国
- 27044
- 2025年11月14日
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- 详细信息
- 技术资料
- 保存条件：
-20°C
- 保质期：
Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
- 英文名：
Obatoclax
- 库存：
1
- 供应商：
BPS Bioscience Inc.
- CAS号：
/
- 规格：
5 mg
Obatoclax, also known as GX15-070, is a novel Bcl-2 homology domain-3 (BH3) mimetic. It occupies a hydrophobic cleft within the BH3 binding groove of Bcl-2, antagonizing Bcl-2 and thus inducing apoptosis. Obatoclax inhibited primary acute myeloid leukemia (AML) progenitor cell proliferation with an average IC50 of 0.18 ± 0.07 µM, and it potently induced apoptosis in primary AML cells with an average IC50 of 3.6 ± 1.2 µM. Obatoclax overcomes Bcl-2-, Bcl-xL-, Bcl-w-, and Mcl-1-mediated resistance to BAX or BAK and to the proteasome inhibitor bortezomib.
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Obatoclax
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