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- 英文名：
L 663536 sodium salt
- 库存：
货期：电询
- 供应商：
MedChemExpress LLC
- CAS号：
118427-55-7
- 规格：
电询
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MK-886 sodium salt
CAS No. : 118427-55-7
MCE 国际站：MK-886 sodium salt
产品活性：MK-886 (L 663536) sodium salt 是一种有效的，细胞可渗透的且具有口服活性的 FLAP (IC50 为 30 nM) 和白三烯生物合成 (完整白细胞和人全血中的 IC50 分别为 3 nM 和 1.1μM) 的抑制剂。MK-886 sodium salt 也是一种非竞争性 PPARα 拮抗剂，可以诱导细胞凋亡。
研究领域：Cell Cycle/DNA Damage | Apoptosis | Immunology/Inflammation | Vitamin D Related/Nuclear Receptor | GPCR/G Protein
作用靶点：PPAR | Leukotriene Receptor | Apoptosis | FLAP
In Vitro: MK-886 sodium salt (0.5-2 μM; 15?hours; primary keratinocytes) treatment reduces keratin-1 expression in a culture of mouse primary keratinocytes.
?Using a transient transfection system in monkey kidney fibroblast CV-1 cells, mouse keratinocyte 308 cells and human lung adenocarcinoma A549 cells, 10 μM MK-886 sodium salt is able to inhibit Wy-14643 activation of PPARα by ~80%. MK-886 sodium salt also decreases PPARα activation by fatty acids in the stable transfection system.
?Although Jurkat cells express all PPAR isoforms, various PPARα and PPARγ agonists are unable to prevent MK-886 sodium salt-induced apoptosis.
In Vivo: MK-886 sodium salt (L 663536; 5 mg/kg; oral administration; male Sprague-Dawley rats) treatment potently inhibits the antigen-induced dyspnea in inbred rats pretreated with methysergide.
?MK-886 sodium salt (L 663536) inhibits leukotriene biosynthesis in vivo in a rat pleurisy model (ED50, 0.2 mg/kg p.o.), an inflamed rat paw model (ED50, 0.8 mg/kg), a model of leukotriene excretion in rat bile following antigen provocation.
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文献和实验Epithelial Sodium Channel in Planar Lipid Bilayers
Amiloride-sensitive Na+ channels belong to the epithelial Na+ channel (ENaC)-degenerin superfamily of ion channels. In addition to their key role in sodium handling, they serve diverse functions in many tissues. Improper functioning of ENaC
Sodium Acetate Precipitation of Small Nucleic Acids
实验步骤 1. Add 2 μl carrier to the nucleic acid solution and mix well. 2. Add 1:10 volume of 3 M sodium acetate and mix thoroughly; for 230 μl of Lower Running Buffer, this will be 23 μl of 3 M
Assembly of Nucleosomal Templates by Salt Dialysis
Because it is convenient to assemble nucleosomal templates through salt dialysis, large amounts of chromatin complexes can be made easily and in a short amount of time. This unit includes instructions for the various salt dialysis schemes (step versus gradient
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