- ￥500 - 700
- MedChemExpress(MCE)
- 美国
- HY-N0182A
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
4°C, stored under nitrogen
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
100 mg/500 mg
| 规格： | 100 mg | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥700.0 |
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Fisetin quarterhydrate
MCE 国际站：Fisetin quarterhydrate
产品活性：Fisetin quarterhydrate是一种在许多水果和蔬菜中发现的天然黄酮醇，具有多种益处，如抗氧化，抗癌，神经保护作用。
研究领域：Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor | Epigenetics | Apoptosis
作用靶点：Sirtuin | TNF Receptor | PPAR
In Vitro: Fisetin quarterhydrate inhibits lipid accumulation and suppresses the expression of PPARγ in 3T3-L1 cells. Fisetin quarterhydrate suppresses early stages of preadipocyte differentiation, and induces expression of Sirt1. Fisetin quarterhydrate facilitates Sirt1-mediated deacetylation of PPARγ and FoxO1, and enhances the association of Sirt1 with the PPARγ promoter, leading to suppression of PPARγ transcriptional activity, thereby repressing adipogenesis. Fisetin quarterhydrate binds to tubulin and stabilizes microtubules with binding characteristics far superior than paclitaxel. Fisetin quarterhydrate treatment of human prostate cancer cells results in robust up-regulation of microtubule associated proteins (MAP)-2 and -4. Fisetin quarterhydrate significantly inhibits PCa cell proliferation, migration, and invasion. Nudc, a protein associated with microtubule motor dynein/dynactin complex that regulates microtubule dynamics, is inhibited with Fisetin quarterhydrate treatment.
In Vivo: Fisetin quarterhydrate treatment to UVB exposed mice results in decreased hyperplasia and reduces infiltration of inflammatory cells. Fisetin quarterhydrate treatment also reduces inflammatory mediators such as COX-2, PGE2 as well as its receptors (EP1- EP4), and MPO activity. Furthermore, Fisetin quarterhydrate reduces the level of inflammatory cytokines TNFα, IL-1β and IL-6 in UVB exposed skin. Fisetin quarterhydrate treatment also reduces cell proliferation markers as well as DNA damage as evidenced by increased expression of p53 and p21 proteins.
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