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CAS No. : 64218-02-6
MCE 国际站:Plaunotol
产品活性:Plaunotol 是一种口服有效的无环二萜醇。Plaunotol 对导致消化性溃疡的幽门螺杆菌具有抗菌活性。Plaunotol 抑制肿瘤血管生成和细胞的增殖活性。Plaunotol 依赖半胱天冬蛋白酶-8 和半胱天冬蛋白酶-9 途径的激活诱导细胞凋亡 (apoptosis) 。Plaunotol 可作为一种潜在的抗结肠癌的抗癌剂。
研究领域:Anti-infection
作用靶点:Bacterial
In Vitro: Plaunotol (0, 10, 20, or 40 μM, 24 or 48 h) shows a significant inhibition of cell proliferation in human colon cancer cell line DLD1.
Plaunotol (40 μM, 24 or 48 h) induces apoptosis in human colon cancer cell line DLD1.
Plaunotol (0, 10, 20, or 40 μM, 48 h) causes activation of caspase-3 in human colon cancer cell line DLD1.
In Vivo: Plaunotol (10, 25 or 50 mg/kg, orally, for 3 h) significantly alleviates gastric mucosal damage in male Wistar rats treated with C48/80 .
Plaunotol (10, 25 or 50 mg/kg, orally, for 3 h) does not affect serum serotonin and histamine concentrations or gastric mucosal blood flow in male Wistar rats treated with C48/80 .
Plaunotol (10, 25 or 50 mg/kg, orally, 3 h) significantly decreases the activity of myeloperoxidase (MPO) and the content of lipid peroxidase thiobarbituric acid reactive substance (TBARS) of gastric mucosa in male Wistar rats treated with C48/80.
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