Niclosamide (GMP),50-65-7

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Niclosamide (GMP)

CAS No. : 50-65-7

MCE 国际站：Niclosamide (GMP)

产品活性：Niclosamide (GMP) 是 GMP 级别的 Niclosamide (HY-B0497)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。Niclosamide (BAY2353) 是一种具有口服活性的用于寄生虫感染研究的抗蠕虫化合物。Niclosamide 是 STAT3 抑制剂，在 HeLa 细胞中的 IC₅₀ 为 0.25 μM。Niclosamide 具有抗癌的生物活性，并能抑制 Vero E6 细胞的 DNA 复制。

研究领域：Anti-infection  |  Stem Cell/Wnt  |  JAK/STAT Signaling

作用靶点：Antibiotic  |  STAT  |  Parasite

In Vitro: Niclosamide (0.6 nM-46 μM) treatment inhibits adrenocortical carcinoma cellular proliferation in BD140A, SW-13, and NCI-H295R cells.
Niclosamide (0.05-5 μM, 24 h) treatment inhibits STAT3-mediated luciferase reporter activity in HeLa cells .
Niclosamide (10 μM) inhibits virus replication in Vero E6 cells<sup>.

Niclosamide (GMP) (up to 2 μM, 24 h) inhibites Zika virus infection in SNB-19 cells.
Niclosamide (GMP) (1.5 μM，5 d) inhibites nuclear factor‐κB ligand (RANKL)-induced transdifferentiation of macrophages into osteoclast precursors, particularly in the early stage of osteoclastogenesis.</sup>

In Vivo: Niclosamide (oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo.

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