产品说明: Clone S16007D (See other available formats) Regulatory Status RUO Other Names P2Y12, ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled, 12 Isotype Rat IgG2b, κ
描述 嘌呤能受体P2Y(P2RY12)是ADP和ATP的受体,与抑制腺苷酸环化酶第二信使系统的G蛋白偶联。P2RY12未被UDP和UTP激活。正常血小板聚集和凝血所需。P2RY12是小胶质细胞的高选择性标记物,它将这些细胞与其他髓系细胞特异性区分开来。 Purinergic Receptor P2Y (P2RY12) is a receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. P2RY12 is not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. P2RY12 is a highly selective marker for microglia that specifically distinguishes these cells from other myeloid cells.
Product Details Isotype Control APC Rat IgG2b, κ Isotype Ctrl Verified Reactivity Mouse Antibody Type Monoclonal Host Species Rat Immunogen Mouse P2RY12. Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration 0.2 mg/ml Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested
Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details Structure P2RY12 is a 347 amino acid protein with a molecular mass of 39.8 kD.
Distribution Tissue distribution: platelets, brain (microglia), lung, appendix, pituitary and adrenal glands. Cellular distribution: cell membrane and cytosol.
Function G-protein coupled receptor that inhibits the adenylyl cyclase second messenger system. Ligand/Receptor ADP and ATP. Cell Type Microglia, Platelets
Biology Area Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers Molecular Family GPCR, Purinergic Receptors
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