BioLegend 696805 PE anti-Nos2

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BioLegend 696805 PE anti-Nos2 (iNOS)
产品简介：
产品品牌：BioLegend
产品货号：696805
产品名称：BioLegend 696805 PE anti-Nos2 (iNOS)
产品规格：25 µg

产品说明：
Clone   W16030C (See other available formats)
Regulatory Status   RUO
Other Names
Nitric oxide synthase 2, nitric oxide synthase 2A, NOS2A, HEP-NOS, inducible nitric oxide synthase (iNOS), Nitric oxide synthase, inducible, Inducible NOS
Isotype   Rat IgG2b, κ

描述
一氧化dan合酶2（NOS2），也称为诱导型一氧化dan合酶（iNOS），包含一个N-末端加氧酶结构域和一个C-末端还原酶结构域，其功能是催化L-精氨酸形成一氧化dan（NO）。NO是一种反应性自由基，作为一种生物信使，在全身具有多种功能，如神经传递、抗菌和抗肿瘤活性。NOS2参与炎症反应并增强PGE2和促炎细胞因子如IL-6和IL-8的合成。NOS2基因在肝脏中高度表达，并可由细菌内毒素和某些细胞因子（包括IL-1、IFNγ和TNFα）的组合诱导。NOS2还具有亚硝化酶活性，并介导细胞质靶蛋白如COX2的半胱氨酸S-亚硝化。
Nitric Oxide Synthase 2 (NOS2), also known as inducible NOS (iNOS), contains an N-terminal oxygenase domain and a C-terminal reductase domain, and functions to catalyze the formation of nitric oxide (NO) from L-arginine. NO is a reactive free radical which acts as a biologic messenger with diverse functions throughout the body, such as neurotransmission, antimicrobial, and antitumor activity. NOS2 is involved in inflammatory responses and enhances the synthesis of PGE2 and proinflammatory cytokines such as IL-6 and IL-8. The NOS2 gene is highly expressed in liver and is inducible by a combination of bacterial endotoxins and certain cytokines, including IL-1, IFNγ and TNFα. NOS2 also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such as COX2.

Product Details
Isotype Control   PE Rat IgG2b, κ Isotype Ctrl
Verified Reactivity   Mouse
Antibody Type   Monoclonal
Host Species   Rat
Immunogen
Partial mouse NOS2 recombinant protein (1-250 a.a.) expressed in E. coli.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide

Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration   0.2 mg/mL

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application   ICFC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure
1144 amino acids with a predicted molecular weight of 130 kD. Contains a flavodoxin-like domain and a FAD-binding FR-type domain.
Distribution   Cytoplasm

Function
NOS2 is a nitric oxide synthase and produces large quantity of NO in response to the stimulation of proinflammatory cytokines. NOS2 plays an important role in host defense against pathogens and participates in anti-tumor processes.

Interaction
Forms a homodimer. Interacts with SLC9A3R1, GAPDH, S100A8, and S100A9.
Biology Area   Cell Biology, Immunology, Innate Immunity

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